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Flab rats: Unfit animals are bad for experiments

作者:公冶寻    发布时间:2019-03-01 09:05:10    

By Mark Mattson RATS and mice are the most widely used animals in biomedical research. They are hugely important in the early stages of drug testing, before clinical trials in humans can begin. Unfortunately, laboratory rats and mice are not up to the job. They are kept under conditions that give them little opportunity for exercise, and at the same time they have access to as much food as they can eat. As a result they are overfed, unfit and obese. Such “couch-potato” animals develop a range of health problems, including insulin resistance, diabetes, high blood pressure, impaired brain function, increased oxidative stress and inflammation. They also have elevated levels of glucose,

 

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